The development of malignant tumors of the face in rats after prolonged treatment with thiourea.
نویسندگان
چکیده
Earlier studies have shown that it is possible to induce a mitotic wave in the livers of rats by three consecutive intraperitoneal injections of large doses of thiourea (14). A subsequent study was undertaken to observe the effect on the liver of prolonged treatment with thiourea. No changes were found after such treatment. However, in five out of six rats which survived for more than 1 year, malignant tumors of the face were observed. The morphology and pathogenesis of these tumors are described below.
منابع مشابه
Malignant tumors in the eyelids and the auricular region of thiourea-treated rats.
During the administration of thiourea to rats for periods of 1 year or longer, squamous-cell carcinomas and sarcomas developed in the region of the face (10). Further experiments on larger groups of animals have now been completed and confirm the first results. In addition to the tumors previously described (10), located between the external ear duct and the eye, a certain number were observed ...
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عنوان ژورنال:
- Cancer research
دوره 14 7 شماره
صفحات -
تاریخ انتشار 1954